A complete sequence and comparative analysis of a SARS-associated virus (Isolate BJ01).
Identifieur interne : 006104 ( Main/Exploration ); précédent : 006103; suivant : 006105A complete sequence and comparative analysis of a SARS-associated virus (Isolate BJ01).
Auteurs : E'De Qin [République populaire de Chine] ; Qingyu Zhu [République populaire de Chine] ; Man Yu [République populaire de Chine] ; Baochang Fan [République populaire de Chine] ; Guohui Chang [République populaire de Chine] ; Bingyin Si [République populaire de Chine] ; Bao'An Yang [République populaire de Chine] ; Wenming Peng [République populaire de Chine] ; Tao Jiang [République populaire de Chine] ; Bohua Liu [République populaire de Chine] ; Yongqiang Deng [République populaire de Chine] ; Hong Liu [République populaire de Chine] ; Yu Zhang [République populaire de Chine] ; Cui'E Wang [République populaire de Chine] ; Yuquan Li [République populaire de Chine] ; Yonghua Gan [République populaire de Chine] ; Xiaoyu Li [République populaire de Chine] ; Fushuang Lü [République populaire de Chine] ; Gang Tan [République populaire de Chine] ; Wuchun Cao [République populaire de Chine] ; Ruifu Yang [République populaire de Chine] ; Jian Wang [République populaire de Chine] ; Wei Li [République populaire de Chine] ; Zuyuan Xu [République populaire de Chine] ; Yan Li [République populaire de Chine] ; Qingfa Wu [République populaire de Chine] ; Wei Lin [République populaire de Chine] ; Weijun Chen [République populaire de Chine] ; Lin Tang [République populaire de Chine] ; Yajun Deng [République populaire de Chine] ; Yujun Han [République populaire de Chine] ; Changfeng Li [République populaire de Chine] ; Meng Lei [République populaire de Chine] ; Guoqing Li [République populaire de Chine] ; Wenjie Li [République populaire de Chine] ; Hong Lü [République populaire de Chine] ; Jianping Shi [République populaire de Chine] ; Zongzhong Tong [République populaire de Chine] ; Feng Zhang [République populaire de Chine] ; Songgang Li [République populaire de Chine] ; Bin Liu [République populaire de Chine] ; Siqi Liu [République populaire de Chine] ; Wei Dong [République populaire de Chine] ; Jun Wang [République populaire de Chine] ; Gane K-S Wong [République populaire de Chine] ; Jun Yu [République populaire de Chine] ; Huanming Yang [République populaire de Chine]Source :
- Chinese science bulletin = Kexue tongbao [ 1001-6538 ] ; 2003.
Abstract
The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS-associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to be involved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the M protein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides no evidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of other possible SARS-related pathogen(s).
DOI: 10.1007/BF03184203
PubMed: 32214698
Affiliations:
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Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Yuquan" sort="Li, Yuquan" uniqKey="Li Y" first="Yuquan" last="Li">Yuquan Li</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name 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Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Zuyuan" sort="Xu, Zuyuan" uniqKey="Xu Z" first="Zuyuan" last="Xu">Zuyuan Xu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Qingfa" sort="Wu, Qingfa" uniqKey="Wu Q" first="Qingfa" last="Wu">Qingfa Wu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Wei" sort="Lin, Wei" uniqKey="Lin W" first="Wei" last="Lin">Wei Lin</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Weijun" sort="Chen, Weijun" uniqKey="Chen W" first="Weijun" last="Chen">Weijun Chen</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Lin" sort="Tang, Lin" uniqKey="Tang L" first="Lin" last="Tang">Lin Tang</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Yajun" sort="Deng, Yajun" uniqKey="Deng Y" first="Yajun" last="Deng">Yajun Deng</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Han, Yujun" sort="Han, Yujun" uniqKey="Han Y" first="Yujun" last="Han">Yujun Han</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Changfeng" sort="Li, Changfeng" uniqKey="Li C" first="Changfeng" last="Li">Changfeng Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Lei, Meng" sort="Lei, Meng" uniqKey="Lei M" first="Meng" last="Lei">Meng Lei</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Guoqing" sort="Li, Guoqing" uniqKey="Li G" first="Guoqing" last="Li">Guoqing Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Wenjie" sort="Li, Wenjie" uniqKey="Li W" first="Wenjie" last="Li">Wenjie Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Hong" sort="Lu, Hong" uniqKey="Lu H" first="Hong" last="Lü">Hong Lü</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Jianping" sort="Shi, Jianping" uniqKey="Shi J" first="Jianping" last="Shi">Jianping Shi</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Tong, Zongzhong" sort="Tong, Zongzhong" uniqKey="Tong Z" first="Zongzhong" last="Tong">Zongzhong Tong</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Feng" sort="Zhang, Feng" uniqKey="Zhang F" first="Feng" last="Zhang">Feng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Songgang" sort="Li, Songgang" uniqKey="Li S" first="Songgang" last="Li">Songgang Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Bin" sort="Liu, Bin" uniqKey="Liu B" first="Bin" last="Liu">Bin Liu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Siqi" sort="Liu, Siqi" uniqKey="Liu S" first="Siqi" last="Liu">Siqi Liu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Wei" sort="Dong, Wei" uniqKey="Dong W" first="Wei" last="Dong">Wei Dong</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Gane K S" sort="Wong, Gane K S" uniqKey="Wong G" first="Gane K-S" last="Wong">Gane K-S Wong</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Jun" sort="Yu, Jun" uniqKey="Yu J" first="Jun" last="Yu">Jun Yu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:32214698</idno><idno type="pmid">32214698</idno><idno type="doi">10.1007/BF03184203</idno><idno type="wicri:Area/PubMed/Corpus">003458</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003458</idno><idno type="wicri:Area/PubMed/Curation">003458</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003458</idno><idno type="wicri:Area/PubMed/Checkpoint">003342</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003342</idno><idno type="wicri:Area/Ncbi/Merge">003532</idno><idno type="wicri:Area/Ncbi/Curation">003532</idno><idno type="wicri:Area/Ncbi/Checkpoint">003532</idno><idno type="wicri:doubleKey">1001-6538:2003:Qin E:a:complete:sequence</idno><idno type="wicri:Area/Main/Merge">006607</idno><idno type="wicri:Area/Main/Curation">006104</idno><idno type="wicri:Area/Main/Exploration">006104</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A complete sequence and comparative analysis of a SARS-associated virus (Isolate BJ01).</title><author><name sortKey="Qin, E De" sort="Qin, E De" uniqKey="Qin E" first="E'De" last="Qin">E'De Qin</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhu, Qingyu" sort="Zhu, Qingyu" uniqKey="Zhu Q" first="Qingyu" last="Zhu">Qingyu Zhu</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yu, Man" sort="Yu, Man" uniqKey="Yu M" first="Man" last="Yu">Man Yu</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Fan, Baochang" sort="Fan, Baochang" uniqKey="Fan B" first="Baochang" last="Fan">Baochang Fan</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chang, Guohui" sort="Chang, Guohui" uniqKey="Chang G" first="Guohui" last="Chang">Guohui Chang</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Si, Bingyin" sort="Si, Bingyin" uniqKey="Si B" first="Bingyin" last="Si">Bingyin Si</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang, Bao An" sort="Yang, Bao An" uniqKey="Yang B" first="Bao'An" last="Yang">Bao'An Yang</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Peng, Wenming" sort="Peng, Wenming" uniqKey="Peng W" first="Wenming" last="Peng">Wenming Peng</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jiang, Tao" sort="Jiang, Tao" uniqKey="Jiang T" first="Tao" last="Jiang">Tao Jiang</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Bohua" sort="Liu, Bohua" uniqKey="Liu B" first="Bohua" last="Liu">Bohua Liu</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Deng, Yongqiang" sort="Deng, Yongqiang" uniqKey="Deng Y" first="Yongqiang" last="Deng">Yongqiang Deng</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Hong" sort="Liu, Hong" uniqKey="Liu H" first="Hong" last="Liu">Hong Liu</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Cui E" sort="Wang, Cui E" uniqKey="Wang C" first="Cui'E" last="Wang">Cui'E Wang</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Yuquan" sort="Li, Yuquan" uniqKey="Li Y" first="Yuquan" last="Li">Yuquan Li</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Gan, Yonghua" sort="Gan, Yonghua" uniqKey="Gan Y" first="Yonghua" last="Gan">Yonghua Gan</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Xiaoyu" sort="Li, Xiaoyu" uniqKey="Li X" first="Xiaoyu" last="Li">Xiaoyu Li</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lu, Fushuang" sort="Lu, Fushuang" uniqKey="Lu F" first="Fushuang" last="Lü">Fushuang Lü</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tan, Gang" sort="Tan, Gang" uniqKey="Tan G" first="Gang" last="Tan">Gang Tan</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cao, Wuchun" sort="Cao, Wuchun" uniqKey="Cao W" first="Wuchun" last="Cao">Wuchun Cao</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang, Ruifu" sort="Yang, Ruifu" uniqKey="Yang R" first="Ruifu" last="Yang">Ruifu Yang</name><affiliation wicri:level="1"><nlm:affiliation>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, 100071 Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Zuyuan" sort="Xu, Zuyuan" uniqKey="Xu Z" first="Zuyuan" last="Xu">Zuyuan Xu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Qingfa" sort="Wu, Qingfa" uniqKey="Wu Q" first="Qingfa" last="Wu">Qingfa Wu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Wei" sort="Lin, Wei" uniqKey="Lin W" first="Wei" last="Lin">Wei Lin</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Weijun" sort="Chen, Weijun" uniqKey="Chen W" first="Weijun" last="Chen">Weijun Chen</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Lin" sort="Tang, Lin" uniqKey="Tang L" first="Lin" last="Tang">Lin Tang</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Yajun" sort="Deng, Yajun" uniqKey="Deng Y" first="Yajun" last="Deng">Yajun Deng</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Han, Yujun" sort="Han, Yujun" uniqKey="Han Y" first="Yujun" last="Han">Yujun Han</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Changfeng" sort="Li, Changfeng" uniqKey="Li C" first="Changfeng" last="Li">Changfeng Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Lei, Meng" sort="Lei, Meng" uniqKey="Lei M" first="Meng" last="Lei">Meng Lei</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Guoqing" sort="Li, Guoqing" uniqKey="Li G" first="Guoqing" last="Li">Guoqing Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Wenjie" sort="Li, Wenjie" uniqKey="Li W" first="Wenjie" last="Li">Wenjie Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Hong" sort="Lu, Hong" uniqKey="Lu H" first="Hong" last="Lü">Hong Lü</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Jianping" sort="Shi, Jianping" uniqKey="Shi J" first="Jianping" last="Shi">Jianping Shi</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Tong, Zongzhong" sort="Tong, Zongzhong" uniqKey="Tong Z" first="Zongzhong" last="Tong">Zongzhong Tong</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Feng" sort="Zhang, Feng" uniqKey="Zhang F" first="Feng" last="Zhang">Feng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Li, Songgang" sort="Li, Songgang" uniqKey="Li S" first="Songgang" last="Li">Songgang Li</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Bin" sort="Liu, Bin" uniqKey="Liu B" first="Bin" last="Liu">Bin Liu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Siqi" sort="Liu, Siqi" uniqKey="Liu S" first="Siqi" last="Liu">Siqi Liu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Wei" sort="Dong, Wei" uniqKey="Dong W" first="Wei" last="Dong">Wei Dong</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Gane K S" sort="Wong, Gane K S" uniqKey="Wong G" first="Gane K-S" last="Wong">Gane K-S Wong</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Jun" sort="Yu, Jun" uniqKey="Yu J" first="Jun" last="Yu">Jun Yu</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name><affiliation wicri:level="1"><nlm:affiliation>2Beijing Genomics Institute, Chinese Academy of Sciences, 101300 Beijing.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><wicri:regionArea>2Beijing Genomics Institute, Chinese Academy of Sciences</wicri:regionArea><wicri:noRegion>Chinese Academy of Sciences</wicri:noRegion></affiliation></author></analytic><series><title level="j">Chinese science bulletin = Kexue tongbao</title><idno type="ISSN">1001-6538</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS-associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to be involved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the M protein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides no evidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of other possible SARS-related pathogen(s).</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Qin, E De" sort="Qin, E De" uniqKey="Qin E" first="E'De" last="Qin">E'De Qin</name></noRegion><name sortKey="Cao, Wuchun" sort="Cao, Wuchun" uniqKey="Cao W" first="Wuchun" last="Cao">Wuchun Cao</name><name sortKey="Chang, Guohui" sort="Chang, Guohui" uniqKey="Chang G" first="Guohui" last="Chang">Guohui Chang</name><name sortKey="Chen, Weijun" sort="Chen, Weijun" uniqKey="Chen W" first="Weijun" last="Chen">Weijun Chen</name><name sortKey="Deng, Yajun" sort="Deng, Yajun" uniqKey="Deng Y" first="Yajun" last="Deng">Yajun Deng</name><name sortKey="Deng, Yongqiang" sort="Deng, Yongqiang" uniqKey="Deng Y" first="Yongqiang" last="Deng">Yongqiang Deng</name><name sortKey="Dong, Wei" sort="Dong, Wei" uniqKey="Dong W" first="Wei" last="Dong">Wei Dong</name><name sortKey="Fan, Baochang" sort="Fan, Baochang" uniqKey="Fan B" first="Baochang" last="Fan">Baochang Fan</name><name sortKey="Gan, Yonghua" sort="Gan, Yonghua" uniqKey="Gan Y" first="Yonghua" last="Gan">Yonghua Gan</name><name sortKey="Han, Yujun" sort="Han, Yujun" uniqKey="Han Y" first="Yujun" last="Han">Yujun Han</name><name sortKey="Jiang, Tao" sort="Jiang, Tao" uniqKey="Jiang T" first="Tao" last="Jiang">Tao Jiang</name><name sortKey="Lei, Meng" sort="Lei, Meng" uniqKey="Lei M" first="Meng" last="Lei">Meng Lei</name><name sortKey="Li, Changfeng" sort="Li, Changfeng" uniqKey="Li C" first="Changfeng" last="Li">Changfeng Li</name><name sortKey="Li, Guoqing" sort="Li, Guoqing" uniqKey="Li G" first="Guoqing" last="Li">Guoqing Li</name><name sortKey="Li, Songgang" sort="Li, Songgang" uniqKey="Li S" first="Songgang" last="Li">Songgang Li</name><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name><name sortKey="Li, Wenjie" sort="Li, Wenjie" uniqKey="Li W" first="Wenjie" last="Li">Wenjie Li</name><name sortKey="Li, Xiaoyu" sort="Li, Xiaoyu" uniqKey="Li X" first="Xiaoyu" last="Li">Xiaoyu Li</name><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><name sortKey="Li, Yuquan" sort="Li, Yuquan" uniqKey="Li Y" first="Yuquan" last="Li">Yuquan Li</name><name sortKey="Lin, Wei" sort="Lin, Wei" uniqKey="Lin W" first="Wei" last="Lin">Wei Lin</name><name sortKey="Liu, Bin" sort="Liu, Bin" uniqKey="Liu B" first="Bin" last="Liu">Bin Liu</name><name sortKey="Liu, Bohua" sort="Liu, Bohua" uniqKey="Liu B" first="Bohua" last="Liu">Bohua Liu</name><name sortKey="Liu, Hong" sort="Liu, Hong" uniqKey="Liu H" first="Hong" last="Liu">Hong Liu</name><name sortKey="Liu, Siqi" sort="Liu, Siqi" uniqKey="Liu S" first="Siqi" last="Liu">Siqi Liu</name><name sortKey="Lu, Fushuang" sort="Lu, Fushuang" uniqKey="Lu F" first="Fushuang" last="Lü">Fushuang Lü</name><name sortKey="Lu, Hong" sort="Lu, Hong" uniqKey="Lu H" first="Hong" last="Lü">Hong Lü</name><name sortKey="Peng, Wenming" sort="Peng, Wenming" uniqKey="Peng W" first="Wenming" last="Peng">Wenming Peng</name><name sortKey="Shi, Jianping" sort="Shi, Jianping" uniqKey="Shi J" first="Jianping" last="Shi">Jianping Shi</name><name sortKey="Si, Bingyin" sort="Si, Bingyin" uniqKey="Si B" first="Bingyin" last="Si">Bingyin Si</name><name sortKey="Tan, Gang" sort="Tan, Gang" uniqKey="Tan G" first="Gang" last="Tan">Gang Tan</name><name sortKey="Tang, Lin" sort="Tang, Lin" uniqKey="Tang L" first="Lin" last="Tang">Lin Tang</name><name sortKey="Tong, Zongzhong" sort="Tong, Zongzhong" uniqKey="Tong Z" first="Zongzhong" last="Tong">Zongzhong Tong</name><name sortKey="Wang, Cui E" sort="Wang, Cui E" uniqKey="Wang C" first="Cui'E" last="Wang">Cui'E Wang</name><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><name sortKey="Wong, Gane K S" sort="Wong, Gane K S" uniqKey="Wong G" first="Gane K-S" last="Wong">Gane K-S Wong</name><name sortKey="Wu, Qingfa" sort="Wu, Qingfa" uniqKey="Wu Q" first="Qingfa" last="Wu">Qingfa Wu</name><name sortKey="Xu, Zuyuan" sort="Xu, Zuyuan" uniqKey="Xu Z" first="Zuyuan" last="Xu">Zuyuan Xu</name><name sortKey="Yang, Bao An" sort="Yang, Bao An" uniqKey="Yang B" first="Bao'An" last="Yang">Bao'An Yang</name><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name><name sortKey="Yang, Ruifu" sort="Yang, Ruifu" uniqKey="Yang R" first="Ruifu" last="Yang">Ruifu Yang</name><name sortKey="Yu, Jun" sort="Yu, Jun" uniqKey="Yu J" first="Jun" last="Yu">Jun Yu</name><name sortKey="Yu, Man" sort="Yu, Man" uniqKey="Yu M" first="Man" last="Yu">Man Yu</name><name sortKey="Zhang, Feng" sort="Zhang, Feng" uniqKey="Zhang F" first="Feng" last="Zhang">Feng Zhang</name><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><name sortKey="Zhu, Qingyu" sort="Zhu, Qingyu" uniqKey="Zhu Q" first="Qingyu" last="Zhu">Qingyu Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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